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A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.

Abstract:

To identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal tumor cases (627 CRC, 313 high-risk adenoma) and 965 controls. In phase 2, we genotyped 42,708 selected SNPs in 2,873 CRC cases and 2,871 controls. In phase 3, we evaluated 11 SNPs showing association at P < 10(-4) in a joint analysis of phases 1 and 2 in 4,287 CRC cases and 3,743 controls. Two SNPs were taken forward ...

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Publisher copy:
10.1038/ng.111

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
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Journal:
Nat Genet
Volume:
40
Issue:
5
Pages:
623-630
Publication date:
2008-05-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:3107cbd6-387f-43f7-8ea5-e7e2f1b7d7ca
Source identifiers:
72265
Local pid:
pubs:72265

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