Thesis icon

Thesis

The role of ERAP1 and HLA-B27 in ankylosing spondylitis pathogenesis

Abstract:

HLA-B27 and ERAP1 are the two strongest predisposing genetic factors to Ankylosing Spondylitis (AS). As a key aminopeptidase in MHC class I presentation, ERAP1 potentially contributes to AS pathogenesis through altering HLA-B27 peptide presentation. In this thesis, I first studied the effect of AS-associated ERAP1 variation on its enzyme activity in vitro. Trimming of two N-terminally extended HLA-B27 epitopes was decreased by K528R mutation; the effect of R725Q was however substrate-depen...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Institution:
University of Oxford
Research group:
Paul Bowness Group
Oxford college:
Linacre College
Department:
Medical Sciences Division - NDORMS (Nuffield Department of Orthopaedics,Rheumatology and Musculoskeletal Sciences)
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
More from this funder
Funding agency for:
Liye Chen
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:3104b83f-215a-490a-a728-ac0e0a271b06
Local pid:
ora:8040

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP