- Abstract:
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HLA-B27 and ERAP1 are the two strongest predisposing genetic factors to Ankylosing Spondylitis (AS). As a key aminopeptidase in MHC class I presentation, ERAP1 potentially contributes to AS pathogenesis through altering HLA-B27 peptide presentation. In this thesis, I first studied the effect of AS-associated ERAP1 variation on its enzyme activity in vitro. Trimming of two N-terminally extended HLA-B27 epitopes was decreased by K528R mutation; the effect of R725Q was however substrate-depen...
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- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
- URN:
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uuid:3104b83f-215a-490a-a728-ac0e0a271b06
- Local pid:
- ora:8040
- Language:
- English
- Keywords:
- Subjects:
- Copyright holder:
- Liye Chen
- Copyright date:
- 2014
Thesis
The role of ERAP1 and HLA-B27 in ankylosing spondylitis pathogenesis
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