p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis.

Journal article

Intact p73 function is shown to be an important determinant of cellular sensitivity to anticancer agents. Inhibition of p73 function by dominant-negative proteins or by mutant p53 abrogates apoptosis and cytotoxicity induced by these agents. A polymorphism encoding either arginine (72R) or proline (72P) at codon 72 of p53 influences inhibition of p73 by a range of p53 mutants identified in squamous cancers. Clinical response following cisplatin-based chemo-radiotherapy for advanced head and n...

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Authors: Bergamaschi, D; Gasco, M; Hiller, L; Sullivan, A; Syed, N

• Publication status: Published
• Journal: Cancer cell
• Volume: 3
• Issue: 4
• Pages: 387-402
• Publication date: 2003-04-01
• DOI: 10.1016/s1535-6108(03)00079-5
• EISSN: 1878-3686
• ISSN: 1535-6108
• Language: English
• Keywords: Carcinoma, Squamous Cell; Immunoblotting; RNA, Small Interfering; Male; Drug Resistance, Neoplasm; Aged; Genes, p53; Polymorphism, Single Nucleotide; Tumor Suppressor Proteins; Immunohistochemistry; Head and Neck Neoplasms; Tumor Cells, Cultured; Mutation; Middle Aged; Drug Therapy; Plasmids; Nuclear Proteins; Prognosis; Genes, Tumor Suppressor; DNA-Binding Proteins; Female; Humans; Adult; Apoptosis