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Journal article

p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis.

Abstract:

Intact p73 function is shown to be an important determinant of cellular sensitivity to anticancer agents. Inhibition of p73 function by dominant-negative proteins or by mutant p53 abrogates apoptosis and cytotoxicity induced by these agents. A polymorphism encoding either arginine (72R) or proline (72P) at codon 72 of p53 influences inhibition of p73 by a range of p53 mutants identified in squamous cancers. Clinical response following cisplatin-based chemo-radiotherapy for advanced head and n...

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Publication status:
Published

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Journal:
Cancer cell
Volume:
3
Issue:
4
Pages:
387-402
Publication date:
2003-04-05
DOI:
EISSN:
1878-3686
ISSN:
1535-6108
URN:
uuid:30f177a9-0e28-4062-a6ec-f516ae20eef1
Source identifiers:
83959
Local pid:
pubs:83959

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