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Adipoyl-6-aminopenicillanic acid is a substrate for deacetoxycephalosporin C synthase (DAOCS)

Abstract:
Adipoyl-6-aminopenicillanic acid 5 was incubated with recombinant DAOCS and the resulting cephalosporin isolated. Adipoyl-6-aminopenicillanic acid 5 is approximately 735 times less efficient as a substrate for DAOCS in vitro (as judged by k(cat)/K(m)) than penicillin N 1.
Publication status:
Published

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
BIOORGANIC and MEDICINAL CHEMISTRY LETTERS
Volume:
6
Issue:
13
Pages:
1579-1584
Publication date:
1996-07-09
DOI:
ISSN:
0960-894X
Source identifiers:
45211
Pubs id:
pubs:45211
UUID:
uuid:30ef96ec-d299-46ed-b42b-13b1d21cd68f
Local pid:
pubs:45211
Deposit date:
2012-12-19

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