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Journal article

Pharmacokinetics of intravenous amodiaquine.

Abstract:

Amodiaquine hydrochloride (3 mg base kg-1) was given by constant rate intravenous injection over 10 min to seven healthy adult male volunteers, and by constant rate infusion (10 mg base kg-1) over 4 h to 10 adult patients admitted to hospital with falciparum malaria. After intravenous injection in volunteers there was considerable variation in plasma concentration profiles between subjects; peak plasma concentrations ranged between 65 and 1921 ng ml-1. A biexponential equation was fitted to t...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Role:
Author
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Journal:
British journal of clinical pharmacology
Volume:
23
Issue:
2
Pages:
127-135
Publication date:
1987-02-05
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
URN:
uuid:30e03661-93f2-4da9-bec5-35c379777782
Source identifiers:
9291
Local pid:
pubs:9291

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