Journal article icon

Journal article

The DISC1 Ser704Cys substitution affects centrosomal localization of its binding partner PCM1 in glia in human brain.

Abstract:

Disrupted-in-schizophrenia 1 (DISC1) has been genetically associated with schizophrenia, and with brain phenotypes including grey matter volume and working memory performance. However, the molecular and cellular basis for these associations remains to be elucidated. One potential mechanism may be via an altered interaction of DISC1 with its binding partners. In this context, we previously demonstrated that one DISC1 variant, Leu607Phe, influenced the extent of centrosomal localization of peri...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1093/hmg/ddq130

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
Journal:
Human molecular genetics
Volume:
19
Issue:
12
Pages:
2487-2496
Publication date:
2010-06-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:30d4611f-2027-4bf9-b623-d28f3bff4c38
Source identifiers:
97981
Local pid:
pubs:97981

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP