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Severity of meningococcal disease associated with genomic bacterial load.

Abstract:

BACKGROUND: Diagnostic polymerase chain reaction (PCR) detection of Neisseria meningitidis has enabled accurate quantification of the bacterial load in patients with meningococcal disease. METHODS: Quantification of the N. meningitidis DNA level by real time-PCR was conducted on whole-blood samples obtained from patients presenting with meningococcal disease to hospitals throughout England and Wales over a 3-year period. Levels were correlated with clinical outcome, infecting serogroup, and ...

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Publisher copy:
10.1086/596707

Authors


Kaczmarski, EB More by this author
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Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume:
48
Issue:
5
Pages:
587-594
Publication date:
2009-03-05
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
URN:
uuid:30ca4655-4f0a-4d35-b47a-4660334d73d9
Source identifiers:
323791
Local pid:
pubs:323791

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