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Antioxidant defense and oxidative damage vary widely among high-altitude residents

Abstract:

OBJECTIVES: People living at high altitude experience unavoidable low oxygen levels (hypoxia). While acute hypoxia causes an increase in oxidative stress and damage despite higher antioxidant activity, the consequences of chronic hypoxia are poorly understood. The aim of the present study is to assess antioxidant activity and oxidative damage in high-altitude natives and upward migrants. METHODS: Individuals from two indigenous high-altitude populations (Amhara, n = 39), (Sherpa, n = 34), one...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1002/ajhb.23039

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Department:
Oxford, MSD, NDM, Tropical Medicine
Role:
Author
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Grant:
HL60917, HL115008, 0452326, 0924726
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Grant:
National Heart, Lung, and Blood Institute: HL115008, HL60917
Publisher:
Wiley Publisher's website
Journal:
American Journal of Human Biology Journal website
Volume:
29
Issue:
6
Pages:
Article: e23039
Publication date:
2017-07-20
DOI:
ISSN:
1520-6300
Pubs id:
pubs:709657
URN:
uri:30afe5c6-3ce3-4f87-a4c7-34d230d782cf
UUID:
uuid:30afe5c6-3ce3-4f87-a4c7-34d230d782cf
Local pid:
pubs:709657
Paper number:
6
Language:
English
Keywords:

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