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Antioxidant defense and oxidative damage vary widely among high-altitude residents

Abstract:

OBJECTIVES: People living at high altitude experience unavoidable low oxygen levels (hypoxia). While acute hypoxia causes an increase in oxidative stress and damage despite higher antioxidant activity, the consequences of chronic hypoxia are poorly understood. The aim of the present study is to assess antioxidant activity and oxidative damage in high-altitude natives and upward migrants. METHODS: Individuals from two indigenous high-altitude populations (Amhara, n = 39), (Sherpa, n = 34), one...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/ajhb.23039

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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Grant:
DivisionofBehavioral
CognitiveSciences:0452326,0924726
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Grant:
BloodInstitute:HL115008,HL60917
NationalHeart,Lung,
Publisher:
Wiley Publisher's website
Journal:
American Journal of Human Biology Journal website
Volume:
29
Issue:
6
Article number:
e23039
Publication date:
2017-07-20
Acceptance date:
2017-06-20
DOI:
ISSN:
1520-6300
Source identifiers:
709657
Language:
English
Keywords:
Pubs id:
pubs:709657
UUID:
uuid:30afe5c6-3ce3-4f87-a4c7-34d230d782cf
Local pid:
pubs:709657
Deposit date:
2017-07-29

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