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Human keratinocyte induction of rapid effector function in antigen-specific memory CD4+ and CD8+ T cells.

Abstract:

The ability of human keratinocytes to present antigen to T cells is controversial and, indeed, it has been suggested that keratinocytes may promote T cell hyporesponsiveness. Furthermore, it is unclear whether keratinocytes can process antigen prior to MHC class I and class II presentation. We tested the ability of keratinocytes to induce functional responses in epitope-specific CD4+ and CD8+ memory T cells using peptides, protein and recombinant expression vectors as sources of antigen. Kera...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200636915

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Role:
Author
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Journal:
European journal of immunology
Volume:
37
Issue:
6
Pages:
1485-1493
Publication date:
2007-06-01
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Source identifiers:
10474

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