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Direct copper-catalyzed three-component synthesis of sulfonamides

Abstract:

First introduced into medicines in the 1930s, the sulfonamide functional group continues to be present in a wide range of contemporary pharmaceuticals and agrochemicals. Despite their popularity in the design of modern bioactive molecules, the underpinning methods for sulfonamide synthesis are essentially unchanged since their introduction, and rely on the use of starting materials with preinstalled sulfur-functionality. Herein we report a direct single-step synthesis of sulfonamides that com...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1021/jacs.8b04532

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More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
Oxford college:
Lincoln College
Role:
Author
ORCID:
0000-0002-0636-6471
Publisher:
American Chemical Society Publisher's website
Journal:
Journal of the American Chemical Society Journal website
Volume:
140
Issue:
28
Pages:
8781–8787
Publication date:
2018-07-02
Acceptance date:
2018-06-20
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
Pubs id:
pubs:858600
URN:
uri:30abc43f-bd1b-4b26-8c3c-be2ebeca3a65
UUID:
uuid:30abc43f-bd1b-4b26-8c3c-be2ebeca3a65
Local pid:
pubs:858600

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