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APC in the regulation of intestinal crypt fission.

Abstract:

The functional effects of APC (adenomatous polyposis coli gene) germ-line mutations on crypt fission and cell proliferation were investigated in the normal intestine of human familial adenomatous polyposis (FAP) and multiple intestinal neoplasia (MIN) mice. Compared with controls, there was a 19-fold increase in the proportion of crypts in fission in FAP colon [95 per cent confidence interval (CI): 11-32, P < 0.0001], and a 75 and 61 per cent increase in MIN colon (95 per cent CI: 1.08-2.8...

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Publication status:
Published

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Authors


Mandir, NK More by this author
Winnett, A More by this author
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Journal:
The Journal of pathology
Volume:
185
Issue:
3
Pages:
246-255
Publication date:
1998-07-05
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
URN:
uuid:308feedc-cc22-4158-a3d4-660b5dfa4b74
Source identifiers:
487577
Local pid:
pubs:487577

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