- Abstract:
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RECQL5 is a member of the RecQ family of helicase which have important functions in DNA repair pathways and maintenance of genome integrity. RECQL5 has recently been identified as a synthetic lethal candidate in various haematological malignancies and has been verified by knockdown to sensitize myeloproliferative neoplasms (MPN) to DNA damaging agents. In this TEP we have expressed purified and determined the first ever crystal structures of RECQL5, in both APO and ADP/Mg2+ bound forms which ...
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- Department:
- Structural Genomics
- Role:
- Researcher
- Department:
- Balliol College
- Role:
- Researcher
- Department:
- Structural Genomics
- Role:
- Researcher
- Publisher:
- University of Oxford
- Publication date:
- 2018
- Keywords:
- Subjects:
- Format:
- Digital
- Documentation:
- A description of the materials and methods is included within the TEP datasheet.
- Copyright date:
- 2018
Dataset
Human RECQL5 Helicase; A Target Enabling Package
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Authors/Creators
Contributors
+ Joseph A Newman
+ Hazel Aitkenhead
+ Pavel Savitsky
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