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Human RECQL5 Helicase; A Target Enabling Package

Version:
3

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Creator, Principal Investigator (PI)

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Researcher
Institution:
University of Oxford
Oxford college:
Balliol College
Role:
Researcher
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Researcher
Publisher:
University of Oxford
Publication date:
2018
Version number:
3
Keywords:
Subjects:
Documentation:
A description of the materials and methods is included within the TEP datasheet. RECQL5 is a member of the RecQ family of helicase which have important functions in DNA repair pathways and maintenance of genome integrity. RECQL5 has recently been identified as a synthetic lethal candidate in various haematological malignancies and has been verified by knockdown to sensitize myeloproliferative neoplasms (MPN) to DNA damaging agents. In this TEP we have expressed purified and determined the fir... Expand documentation
UUID:
uuid:308b8d6e-c67b-4c25-b9fb-226efbe8c479
Deposit date:
2018-05-08

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