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Transplantation of skeletal myoblasts secreting an IL-1 inhibitor modulates adverse remodeling in infarcted murine myocardium.

Abstract:

After myocardial infarction (MI), adverse remodeling with left ventricular (LV) dilatation is a major determinant of poor outcome. Skeletal myoblast (SkM) implantation improves cardiac function post-MI, although the mechanism is unclear. IL-1 influences post-MI hypertrophy and collagen turnover and is implicated in SkM death after grafting. We hypothesized that SkM expressing secretory IL-1 receptor antagonist (sIL-1ra) at MI border zones would specifically attenuate adverse remodeling and ex...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0306205101

Authors


Murtuza, B More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Beauchamp, JR More by this author
Smolenski, RT More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
101
Issue:
12
Pages:
4216-4221
Publication date:
2004-03-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:3077bc2a-1a52-427f-af4e-2d4e1a5091b8
Source identifiers:
223489
Local pid:
pubs:223489

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