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Co-orthology of Pax4 and Pax6 to the fly eyeless gene: molecular phylogenetic, comparative genomic, and embryological analyses.

Abstract:

The functional equivalence of Pax6/eyeless genes across distantly related animal phyla has been one of central findings on which evo-devo studies is based. In this study, we show that Pax4, in addition to Pax6, is a vertebrate ortholog of the fly eyeless gene (and its duplicate, twin of eyeless [toy] gene, unique to Insecta). Molecular phylogenetic trees published to date placed the Pax4 gene outside the Pax6/eyeless subgroup as if the Pax4 gene originated from a gene duplication before the o...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
Journal:
Evolution and development
Volume:
13
Issue:
5
Pages:
448-459
Publication date:
2011-01-01
DOI:
EISSN:
1525-142X
ISSN:
1520-541X
URN:
uuid:3075d41e-063d-42d9-bfe0-75639852b2a4
Source identifiers:
425943
Local pid:
pubs:425943

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