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Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators.

Abstract:

The role of the transcription factor NF-kappaB in the pathogenesis of rheumatoid arthritis has long been a subject of controversy. We used an adenoviral technique of blocking NF-kappaB through overexpression of the inhibitory subunit IkappaBalpha, which has the advantage that it can be used in the diseased tissue itself, with >90% of the synovial macrophages, fibroblasts, and T cells infected. We found that the spontaneous production of tumor necrosis factor alpha and other pro-inflammator...

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Publisher copy:
10.1073/pnas.96.10.5668

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
96
Issue:
10
Pages:
5668-5673
Publication date:
1999-05-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:306fbae2-2bfc-420c-a5d1-a77ba62229f6
Source identifiers:
481582
Local pid:
pubs:481582

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