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Structure guided development of potent reversibly binding penicillin binding protein inhibitors.

Abstract:
Following from the evaluation of different types of electrophiles, combined modeling and crystallographic analyses are used to generate potent boronic acid based inhibitors of a penicillin binding protein. The results suggest that a structurally informed approach to penicillin binding protein inhibition will be useful for the development of both improved reversibly binding inhibitors, including boronic acids, and acylating inhibitors, such as β-lactams.
Publication status:
Published

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Publisher copy:
10.1021/ml100260x

Authors


Zervosen, A More by this author
Sauvage, E More by this author
Simmons, KJ More by this author
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Journal:
ACS medicinal chemistry letters
Volume:
2
Issue:
3
Pages:
219-223
Publication date:
2011-03-05
DOI:
EISSN:
1948-5875
ISSN:
1948-5875
URN:
uuid:3066284c-4c58-4b07-94cc-473002498754
Source identifiers:
132438
Local pid:
pubs:132438

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