Journal article icon

Journal article

Stereoselective preparation of lipidated carboxymethyl-proline/pipecolic acid derivatives via coupling of engineered crotonases with an alkylmalonyl-CoA synthetase.

Abstract:
The trisubstituted enolate- and C-C bond-forming capacities of engineered carboxymethylproline synthases CMPSs are coupled with the malonyl-CoA synthetase MatB to enable stereoselective preparation of 5- and 6-membered N-heterocycles functionalised with alkyl-substituted carboxymethyl side chains, starting from achiral alkyl-substituted malonic acids and L-amino acid semialdehydes. The results illustrate the biocatalytic utility of crotonases in tandem enzyme-catalysed reactions for stereoselective synthesis.
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1039/c3ob41525b

Authors


Expand authors...
Journal:
Organic and biomolecular chemistry
Volume:
11
Issue:
47
Pages:
8191-8196
Publication date:
2013-12-05
DOI:
EISSN:
1477-0539
ISSN:
1477-0520
URN:
uuid:3065e355-1f80-4898-bdbc-8fc817d7b54c
Source identifiers:
434239
Local pid:
pubs:434239

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP