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The role of BMP signalling in HSC ontogeny

Abstract:

The haematopoietic stem cell (HSC) is found in the adult human bone marrow, where it gives rise to all the circulating blood cells throughout adulthood. Understanding the signalling events that programme these cells during development will improve HSC in vitro culture, their generation from embryonic stem cells or induced pluripotent stem cells, and their potential therapeutic application. HSCs bud from the floor of the dorsal aorta and seed the bone marrow via circulation. The pr...

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Institution:
University of Oxford
Oxford college:
Brasenose College
Department:
Medical Sciences Division - Molecular Medicine,Weatherall Institute of
Role:
Author

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Role:
Supervisor
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Funding agency for:
Stuart J Meiklejohn
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:305597a8-b8cb-42ff-88fd-34b3dd5bf39b
Local pid:
ora:8522
Language:
English
Keywords:
Subjects:

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