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Journal article

Pharmacological evidence for a key role of voltage-gated K+ channels in the function of rat aortic smooth muscle cells.

Abstract:

The role of voltage-dependent (I(K(v))) and large conductance Ca(2+)-activated (BK(Ca)) K(+) currents in the function of the rat aorta was investigated using specific BK(Ca) and K(V) channel inhibitors in single rat aortic myocytes (RAMs) with patch-clamp technique and in endothelium-denuded aortic rings with isometric tension measurements. The whole-cell K(+) currents were recorded in RAMs dialysed with 200 and 444 nm Ca(2+) and in perforated-patch configuration. Electrophysiological analysi...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bjp.0705957

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Hutchings, SR More by this author
Smirnov, SV More by this author
Journal:
British journal of pharmacology
Volume:
143
Issue:
2
Pages:
303-317
Publication date:
2004-09-05
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
URN:
uuid:30416cc3-8ab9-4e6a-b129-5ed1c11d712e
Source identifiers:
216309
Local pid:
pubs:216309

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