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Symmetrically reduced stiffness and increased extensibility in compression and tension at the mineralized fibrillar level in rachitic bone.

Abstract:

In metabolic bone diseases, the alterations in fibrillar level bone-material quality affecting macroscopic mechanical competence are not well-understood quantitatively. Here, we quantify the fibrillar level deformation in cantilever bending in a mouse model for hereditary rickets (Hpr). Microfocus in-situ synchrotron small-angle X-ray scattering (SAXS) combined with cantilever bending was used to resolve nanoscale fibril strain in tensile- and compressive tissue regions separately, with quant...

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Publication status:
Published

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Publisher copy:
10.1016/j.bone.2012.10.029

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Journal:
Bone
Volume:
52
Issue:
2
Pages:
689-698
Publication date:
2013-02-05
DOI:
EISSN:
1873-2763
ISSN:
8756-3282
URN:
uuid:30289edb-b5ab-48bc-9f97-cd54beb43c8a
Source identifiers:
358285
Local pid:
pubs:358285

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