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An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment

Abstract:

The role of DNA sequence in determining chromatin state is incompletely understood. We have previously demonstrated that large chromosomal segments from human cells recapitulate their native chromatin state in mouse cells, but the relative contribution of local sequences versus their genomic context remains unknown. In this study, we compare orthologous chromosomal regions for which the human locus establishes prominent sites of Polycomb complex recruitment in pluripotent stem cells, whereas ...

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Publisher copy:
10.1038/emboj.2011.399

Authors


Smith, AJH More by this author
De Gobbi, M More by this author
Flenley, M More by this author
Hughes, JR More by this author
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Journal:
EMBO Journal
Volume:
31
Issue:
2
Pages:
317-329
Publication date:
2012-01-18
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:3022ff68-d913-40de-bf56-d6042fd83e50
Source identifiers:
315694
Local pid:
pubs:315694

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