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What have we learnt from targeted anti-TNF therapy?

Abstract:

Anti-tumour necrosis factor (anti-TNF) therapy of patients with rheumatoid arthritis dates back to 1992, when the first proof-of-principle trials were performed in London by Maini and Feldmann. Considerable studies of the mechanism of action were performed, and insights into the way in which anti-TNF therapy delivers its benefit were obtained. In this brief review, certain aspects of knowledge acquired and the many gaps will be reviewed. Focus will be on the TNF-dependent cytokine cascade and...

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Publication status:
Published

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Publisher copy:
10.1136/ard.2009.117143

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Paleolog, E More by this author
Journal:
Annals of the rheumatic diseases
Volume:
69 Suppl 1
Issue:
SUPPL. 1
Pages:
i97-i99
Publication date:
2010-01-05
DOI:
EISSN:
1468-2060
ISSN:
0003-4967
URN:
uuid:30178715-c861-4334-9862-5d2f4421ac65
Source identifiers:
224432
Local pid:
pubs:224432

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