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Targeting inflammation and oxidative stress in atrial fibrillation: role of 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibition with statins.

Abstract:

SIGNIFICANCE: Atrial fibrillation (AF) is a burgeoning health-care problem, and the currently available therapeutic armamentarium is barely efficient. Experimental and clinical evidence implicates inflammation and myocardial oxidative stress in the pathogenesis of AF. RECENT ADVANCES: Local and systemic inflammation has been found to both precede and follow the new onset of AF, and NOX2-dependent generation of reactive oxygen species in human right atrial samples has been independently associ...

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Publication status:
Published

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Publisher copy:
10.1089/ars.2013.5542

Authors


Pinho-Gomes, AC More by this author
Brandes, RP More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Journal:
Antioxidants and redox signaling
Volume:
20
Issue:
8
Pages:
1268-1285
Publication date:
2014-03-05
DOI:
EISSN:
1557-7716
ISSN:
1523-0864
URN:
uuid:300a25ef-8b4e-435b-bf76-c07f3760f961
Source identifiers:
416669
Local pid:
pubs:416669

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