Journal article
Suppression mediated by anergic CD4+ T cells requires stimulation by MHC-peptide complexes and can be induced in the presence of costimulation.
- Abstract:
-
BACKGROUND: In this study, we have investigated the mechanisms involved in both the induction of suppressive anergy, the stability of the anergy induced, and the possible mechanisms by which the response of immunocompetent CD4+ T cells are suppressed. METHODS: We used immobilized anti-CD3 monoclonal antibody (mAb) to induce anergy in T helper (Th) 1 and Th0 cells reactive with MHC class II molecule H2 I-Ab. RESULTS: We observed that suppressive anergy was induced independently of costimulatio...
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- Publication status:
- Published
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- Publisher copy:
- 10.1097/00007890-200108150-00004
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Bibliographic Details
- Journal:
- Transplantation
- Volume:
- 72
- Issue:
- 3
- Pages:
- 369-376
- Publication date:
- 2001-08-01
- DOI:
- EISSN:
-
1534-6080
- ISSN:
-
0041-1337
- Source identifiers:
-
135929
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:135929
- UUID:
-
uuid:2ffa7773-fcc6-4e9c-9860-9af917ba2bae
- Local pid:
- pubs:135929
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2001
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