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Suppression mediated by anergic CD4+ T cells requires stimulation by MHC-peptide complexes and can be induced in the presence of costimulation.

Abstract:

BACKGROUND: In this study, we have investigated the mechanisms involved in both the induction of suppressive anergy, the stability of the anergy induced, and the possible mechanisms by which the response of immunocompetent CD4+ T cells are suppressed. METHODS: We used immobilized anti-CD3 monoclonal antibody (mAb) to induce anergy in T helper (Th) 1 and Th0 cells reactive with MHC class II molecule H2 I-Ab. RESULTS: We observed that suppressive anergy was induced independently of costimulatio...

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Publication status:
Published

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Journal:
Transplantation
Volume:
72
Issue:
3
Pages:
369-376
Publication date:
2001-08-01
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
Source identifiers:
135929

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