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Upregulation of lipocalin-2 in human papillomavirus-positive keratinocytes and cutaneous squamous cell carcinomas

Abstract:

It has been demonstrated previously that E7 oncogene expression of human papillomavirus (HPV) type 8 in keratinocytes induces cell invasion and accelerated differentiation. Looking for cellular genes deregulated by HPV-8 E7, lipocalin-2 was identified as being upregulated in these cells by cDNA microarray analysis. Lipocalin-2 is known to be overexpressed in many human cancers and is implicated in the regulation of cell proliferation, differentiation and apoptosis. In this study, increased le...

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Publisher copy:
10.1099/vir.0.025064-0

Authors


Zigrino, P More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
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Journal:
Journal of General Virology
Volume:
92
Issue:
2
Pages:
395-401
Publication date:
2011-02-05
DOI:
EISSN:
1465-2099
ISSN:
0022-1317
URN:
uuid:2ff1f6d2-1d47-4dd7-b0e1-a90f3dce1478
Source identifiers:
179124
Local pid:
pubs:179124
Language:
English

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