Journal article icon

Journal article

Reshaping a therapeutic CD4 antibody.

Abstract:

An immunosuppressive rat antibody (Campath-9) against human CD4 has been reshaped for use in the management of autoimmunity and the prevention of graft rejection. Two different forms of the reshaped antibody were produced that derive their heavy chain variable region framework sequences from the human myeloma proteins KOL or NEW. When compared to a chimeric form of the CD4 antibody, the avidity of the KOL-based reshaped antibody was only slightly reduced, whereas that of the NEW-based reshape...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1073/pnas.88.10.4181

Authors


Gorman, SD More by this author
Routledge, EG More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
88
Issue:
10
Pages:
4181-4185
Publication date:
1991-05-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:2fd332c6-babb-4e0f-bc45-24cba733beec
Source identifiers:
18338
Local pid:
pubs:18338

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP