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Platelet PECAM-1 inhibits thrombus formation in vivo.

Abstract:

Platelet endothelial cell adhesion molecule-1 (PECAM-1) is a cell surface glycoprotein receptor expressed on a range of blood cells, including platelets, and on vascular endothelial cells. PECAM-1 possesses adhesive and signaling properties, the latter being mediated by immunoreceptor tyrosine-based inhibitory motifs present on the cytoplasmic tail of the protein. Recent studies in vitro have demonstrated that PECAM-1 signaling inhibits the aggregation of platelets. In the present study we ha...

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Publisher copy:
10.1182/blood-2005-04-1512

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Journal:
Blood
Volume:
107
Issue:
2
Pages:
535-541
Publication date:
2006-01-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:2fc81008-7f93-4c89-a269-aadd8ab0fd63
Source identifiers:
244766
Local pid:
pubs:244766

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