Platelet endothelial cell adhesion molecule-1 (PECAM-1) is a cell surface glycoprotein receptor expressed on a range of blood cells, including platelets, and on vascular endothelial cells. PECAM-1 possesses adhesive and signaling properties, the latter being mediated by immunoreceptor tyrosine-based inhibitory motifs present on the cytoplasmic tail of the protein. Recent studies in vitro have demonstrated that PECAM-1 signaling inhibits the aggregation of platelets. In the present study we ha...Expand abstract
- Publisher copy:
- Copyright date:
Platelet PECAM-1 inhibits thrombus formation in vivo.
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record