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Journal article

Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia

Abstract:

BACKGROUND: In mammalians, HIF is a master regulator of hypoxia gene expression through direct binding to DNA, while its role in microRNA expression regulation, critical in the hypoxia response, is not elucidated genome wide. Our aim is to investigate in depth the regulation of microRNA expression by hypoxia in the breast cancer cell line MCF-7, establish the relationship between microRNA expression and HIF binding sites, pri-miRNA transcription and microRNA processing gene expression. METHOD...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/1476-4598-13-28

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Publisher:
BioMed Central Publisher's website
Journal:
Molecular Cancer Journal website
Volume:
13
Issue:
1
Pages:
28
Publication date:
2014-01-01
DOI:
EISSN:
1476-4598
ISSN:
1476-4598
Source identifiers:
449153
Language:
English
Keywords:
Pubs id:
pubs:449153
UUID:
uuid:2fc62b06-0f0a-4bdc-b274-656a39055598
Local pid:
pubs:449153
Deposit date:
2014-02-22

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