Journal article icon

Journal article

Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia

Abstract:

BACKGROUND: In mammalians, HIF is a master regulator of hypoxia gene expression through direct binding to DNA, while its role in microRNA expression regulation, critical in the hypoxia response, is not elucidated genome wide. Our aim is to investigate in depth the regulation of microRNA expression by hypoxia in the breast cancer cell line MCF-7, establish the relationship between microRNA expression and HIF binding sites, pri-miRNA transcription and microRNA processing gene expression. METHOD...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1186/1476-4598-13-28

Authors


More by this author
Institution:
University of Oxford
Department:
The Wellcome Trust Centre for Human Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP
Role:
Author
More by this author
Institution:
University of Oxford
Department:
The Wellcome Trust Centre for Human Genetics
Role:
Author
Expand authors...
Publisher:
BioMed Central Publisher's website
Journal:
Molecular Cancer Journal website
Volume:
13
Issue:
1
Pages:
28
Publication date:
2014-01-05
DOI:
EISSN:
1476-4598
ISSN:
1476-4598
URN:
uuid:2fc62b06-0f0a-4bdc-b274-656a39055598
Source identifiers:
449153
Local pid:
pubs:449153

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP