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Cytoplasmic location of factor-inhibiting hypoxia-inducible factor is associated with an enhanced hypoxic response and a shorter survival in invasive breast cancer.

Abstract:

INTRODUCTION: Hypoxia-inducible factor (HIF)-1alpha levels in invasive breast carcinoma have been shown to be an adverse prognostic indicator. Cellular HIF-1alpha activity is regulated by factor-inhibiting hypoxia-inducible factor 1 (FIH-1). In hypoxia, FIH-1 hydroxylation of Asn803 within the C-terminal transactivation domain does not occur and HIF-1alpha forms a fully active transcriptional complex. The present study investigates the role of FIH-1 in invasive breast carcinoma and its corre...

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Publication status:
Published

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Publisher copy:
10.1186/bcr1838

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Clinical Lab Sciences
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Journal:
Breast cancer research : BCR
Volume:
9
Issue:
6
Pages:
R89
Publication date:
2007
DOI:
EISSN:
1465-542X
ISSN:
1465-5411
URN:
uuid:2fbc794e-3acb-4a9b-925b-2f208c122d71
Source identifiers:
119040
Local pid:
pubs:119040

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