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The effects of a met-enkephalin analogue on ACTH, beta-LPH, beta-endorphin and MET-enkephalin in patients with adrenocortical disease.

Abstract:

Thirteen patients with either Addison's disease, or Cushing's disease treated by bilateral adrenalectomy, were infused with the long-acting met-enkephalin analogue DAMME. In patients with Addison's disease significant and pronounced falls in ACTH and N- and C-terminal beta-LPH were seen; chromatography suggested that beta-endorphin fell concomitantly. Three out of four patients with Cushing's disease who had not received pituitary irradiation, also showed a decrease in plasma ACTH and N- and ...

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Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
Journal:
Clinical endocrinology
Volume:
14
Issue:
5
Pages:
471-478
Publication date:
1981-05-05
DOI:
EISSN:
1365-2265
ISSN:
0300-0664
URN:
uuid:2faf504a-ddd9-4af1-9ccb-cb93e8db0b92
Source identifiers:
138610
Local pid:
pubs:138610

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