The identification of surface proteins of Burkholderia pseudomallei.

Journal article

Burkholderia pseudomallei, the causative agent of the disease melioidosis is a human pathogen endemic in Northern Australia and South-East Asia. At present there is no available vaccine or effective treatment for this disease. Surface proteins play crucial roles in the host-pathogen interaction and have been exploited as vaccine candidates and diagnostic targets. Therefore, we wished to identify immunogenic surface proteins of B. pseudomallei. To this end we used two proteomic-based approache...

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Authors: Harding, S; Sarkar-Tyson, M; Smither, S; Atkins, T; Oyston, P

• Publication status: Published
• Journal: Vaccine
• Volume: 25
• Issue: 14
• Pages: 2664-2672
• Publication date: 2007-03-01
• DOI: 10.1016/j.vaccine.2006.12.006
• EISSN: 1873-2518
• ISSN: 0264-410X
• Language: English
• Keywords: Burkholderia pseudomallei; Biotinylation; Humans; Electrophoresis, Gel, Two-Dimensional; Bacterial Outer Membrane Proteins; Proteomics