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Endothelin: an important factor in acute renal failure?

Abstract:

Very low concentrations of the vasoconstrictor peptide endothelin cause intense long-lasting renal vasoconstriction. In the isolated perfused rat kidney, the concentration of endothelin required to reduce blood-flow by 50% is 200 pmol/l, compared with 1000 pmol/l angiotensin II (previously the most potent known vasoconstrictor). Whereas angiotensin II has little effect on the glomerular filtration rate (GFR), a rise in endothelin from 100 to 800 pmol/l reduces GFR by 90%. Endothelin is probab...

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Publication status:
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Biomedical Research Centre
Ledingham, JG More by this author
Journal:
Lancet (London, England)
Volume:
2
Issue:
8621
Pages:
1179-1182
Publication date:
1988-11-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:2f90d091-373e-4132-8a27-6feda10948d3
Source identifiers:
22843
Local pid:
pubs:22843

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