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Power consequences of linkage disequilibrium variation between populations.

Abstract:

We quantify the degree to which LD differences exist in the human genome and investigates the consequences that variations in patterns of LD between populations can have on the power of case-control or family-trio association studies. Although only a small proportion of SNPs show significant LD differences (0.8-5%), these can introduce artificial signals of associations and reduce the power to detect true associations in case-control designs, even when meta-analytic approaches are used to acc...

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Publication status:
Published

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Publisher copy:
10.1002/gepi.20366

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
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Journal:
Genetic epidemiology
Volume:
33
Issue:
2
Pages:
128-135
Publication date:
2009-02-05
DOI:
EISSN:
1098-2272
ISSN:
0741-0395
URN:
uuid:2f869845-f135-4e31-8a2a-e39980531ff8
Source identifiers:
34398
Local pid:
pubs:34398

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