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A trade-off between oxidative stress resistance and DNA repair plays a role in the evolution of elevated mutation rates in bacteria.

Abstract:

The dominant paradigm for the evolution of mutator alleles in bacterial populations is that they spread by indirect selection for linked beneficial mutations when bacteria are poorly adapted. In this paper, we challenge the ubiquity of this paradigm by demonstrating that a clinically important stressor, hydrogen peroxide, generates direct selection for an elevated mutation rate in the pathogenic bacterium Pseudomonas aeruginosa as a consequence of a trade-off between the fidelity of DNA repai...

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Publication status:
Published

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Publisher copy:
10.1098/rspb.2013.0007

Authors


Torres-Barceló, C More by this author
Buckling, A More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Journal:
Proceedings. Biological sciences / The Royal Society
Volume:
280
Issue:
1757
Pages:
20130007
Publication date:
2013-04-05
DOI:
EISSN:
1471-2954
ISSN:
0962-8452
URN:
uuid:2f7ed08e-a60f-455a-b06f-09ac59f8b0f6
Source identifiers:
387183
Local pid:
pubs:387183

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