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Thesis

Assaying the biological role of the PKD1L1-PKD2 interaction

Abstract:

Polycystins are a family of transmembrane proteins found in metazoan species that play a plethora of roles, at multiple stages, throughout the lifespan of the animal organism. In human, two loci encoding polycystins, PKD1 and PKD2, were found to be causative of autosomal dominant polycystic kidney disease. Later studies identified these two genes in other organisms, such as mouse and zebrafish, which served as models for investigating the function and regulation of the two proteins. PKD1 a...

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Department:
University of Oxford, MRC Harwell

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Department:
MRC Harwell
Role:
Supervisor
Department:
University of Oxford
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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