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Spatiotemporal dynamics of DNA repair proteins following laser microbeam induced DNA damage - When is a DSB not a DSB?

Abstract:

The formation of DNA lesions poses a constant threat to cellular stability. Repair of endogenously and exogenously produced lesions has therefore been extensively studied, although the spatiotemporal dynamics of the repair processes has yet to be fully understood. One of the most recent advances to study the kinetics of DNA repair has been the development of laser microbeams to induce and visualize recruitment and loss of repair proteins to base damage in live mammalian cells. However, a numb...

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Journal:
Mutation Research - Genetic Toxicology and Environmental Mutagenesis
Volume:
756
Issue:
1-2
Pages:
14-20
Publication date:
2013-05-30
DOI:
EISSN:
1879-3592
ISSN:
1383-5718
URN:
uuid:2f688dc8-6b93-4d0f-b60d-7c482a8dc626
Source identifiers:
429588
Local pid:
pubs:429588
Language:
English
Keywords:

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