Journal article icon

Journal article

Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-alpha therapy in rheumatoid arthritis.

Abstract:

Treatment with a chimeric mAb to TNF-alpha has been shown to suppress inflammation and improve patient well-being in rheumatoid arthritis (RA), but the mechanisms of action of such treatment have not been fully explored. Here we show that in vivo administration of anti-TNF-alpha Ab, using a longitudinal analysis, results in the rapid down-regulation of a spectrum of cytokines, cytokine inhibitors, and acute-phase proteins. Marked diurnal variation in the serum levels of some of these were det...

Expand abstract
Publication status:
Published

Actions


Authors


Charles, P More by this author
Elliott, MJ More by this author
Kalden, JR More by this author
Expand authors...
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
163
Issue:
3
Pages:
1521-1528
Publication date:
1999-08-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:2f6276f0-3066-4752-997f-b334aaafcaaa
Source identifiers:
481579
Local pid:
pubs:481579

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP