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Protective efficacy of a novel simian adenovirus vaccine against lethal MERS-CoV challenge in a transgenic human DPP4 mouse model

Abstract:

Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel zoonotic virus that causes severe respiratory disease in humans with case fatality rates close to 40%, but for which no vaccines are available. Here, we evaluated the utility of ChAdOx1, a promising replication-deficient simian adenovirus vaccine vector platform with an established safety profile in humans and dromedary camels, for MERS-CoV vaccine development. Using a transgenic lethal BALB/c MERS-CoV mouse model we showed th...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41541-017-0029-1

Authors


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Department:
Oxford, MSD, NDM, Jenner Institute
Role:
Author
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Department:
Oxford, MSD, NDM, Jenner Institute
Role:
Author
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Grant:
Intramural Research Program of the National Institute of Allergy and Infectious Diseases
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Grant:
Confidence in Concept scheme to GMW through the LSTM Tropical Infectious Disease Consortium
Publisher:
Springer Nature Publisher's website
Journal:
npj Vaccines Journal website
Volume:
2
Pages:
Article: 28
Publication date:
2017-10-16
Acceptance date:
2017-09-15
DOI:
ISSN:
2059-0105
Pubs id:
pubs:728935
URN:
uri:2f4ddc26-9f71-46a2-b192-0bc47c67f1e7
UUID:
uuid:2f4ddc26-9f71-46a2-b192-0bc47c67f1e7
Local pid:
pubs:728935

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