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The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase.

Abstract:

Post-translational modification of proteins by poly(ADP-ribosyl)ation regulates many cellular pathways that are critical for genome stability, including DNA repair, chromatin structure, mitosis and apoptosis. Poly(ADP-ribose) (PAR) is composed of repeating ADP-ribose units linked via a unique glycosidic ribose-ribose bond, and is synthesized from NAD by PAR polymerases. PAR glycohydrolase (PARG) is the only protein capable of specific hydrolysis of the ribose-ribose bonds present in PAR chain...

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Publisher copy:
10.1038/nature10404

Authors


Dunstan, MS More by this author
Barkauskaite, E More by this author
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Journal:
Nature
Volume:
477
Issue:
7366
Pages:
616-620
Publication date:
2011-09-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:2f4a41f5-e5e9-4105-90b5-ffcd362468e0
Source identifiers:
376193
Local pid:
pubs:376193

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