- Abstract:
-
Growth in normal and tumour cells is regulated by evolutionarily conserved extracellular inputs from the endocrine insulin receptor (InR) signalling pathway and by local nutrients. Both signals modulate activity of the intracellular TOR kinase, with nutrients at least partly acting through changes in intracellular amino acid levels mediated by amino acid transporters. We show that in Drosophila, two molecules related to mammalian proton-assisted SLC36 amino acid transporters (PATs), CG3424 an...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1242/dev.01821
-
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- Journal:
- Development (Cambridge, England)
- Volume:
- 132
- Issue:
- 10
- Pages:
- 2365-2375
- Publication date:
- 2005-05-05
- DOI:
- EISSN:
-
1477-9129
- ISSN:
-
0950-1991
- URN:
-
uuid:2f48a95d-58c1-4637-82ec-12dc3b1776fb
- Source identifiers:
-
113604
- Local pid:
- pubs:113604
- Language:
- English
- Keywords:
- Copyright date:
- 2005
Journal article
PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids.
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