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PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids.

Abstract:

Growth in normal and tumour cells is regulated by evolutionarily conserved extracellular inputs from the endocrine insulin receptor (InR) signalling pathway and by local nutrients. Both signals modulate activity of the intracellular TOR kinase, with nutrients at least partly acting through changes in intracellular amino acid levels mediated by amino acid transporters. We show that in Drosophila, two molecules related to mammalian proton-assisted SLC36 amino acid transporters (PATs), CG3424 an...

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Publication status:
Published

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Publisher copy:
10.1242/dev.01821

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Development (Cambridge, England)
Volume:
132
Issue:
10
Pages:
2365-2375
Publication date:
2005-05-05
DOI:
EISSN:
1477-9129
ISSN:
0950-1991
URN:
uuid:2f48a95d-58c1-4637-82ec-12dc3b1776fb
Source identifiers:
113604
Local pid:
pubs:113604

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