Journal article icon

Journal article

Delineation of a unique protein-protein interaction site on the surface of the estrogen receptor.

Abstract:

Recent studies have identified a series of estrogen receptor (ER)-interacting peptides that recognize sites that are distinct from the classic coregulator recruitment (AF2) region. Here, we report the structural and functional characterization of an ERalpha-specific peptide that binds to the liganded receptor in an AF2-independent manner. The 2-A crystal structure of the ER/peptide complex reveals a binding site that is centered on a shallow depression on the beta-hairpin face of the ligand-b...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1073/pnas.0407189102

Authors


Heldring, N More by this author
Gustafsson, JA More by this author
Treuter, E More by this author
Hubbard, RE More by this author
Expand authors...
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
102
Issue:
10
Pages:
3593-3598
Publication date:
2005-03-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:2f434095-7dfc-4c9f-9680-2752a25dcc7e
Source identifiers:
317563
Local pid:
pubs:317563

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP