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ACTH and alpha-MSH inhibit leptin expression and secretion in 3T3-L1 adipocytes: model for a central-peripheral melanocortin-leptin pathway.

Abstract:

Leptin is the 167 amino-acid protein product of the Lep (obese) gene that is released predominantly from adipose tissue and circulates at levels related to the amount of fat. Leptin expression is hormonally regulated: insulin and glucocorticoids are stimulators, while inhibitors include beta-adrenergic agonists and testosterone. Recently, adenylate cyclase-coupled melanocortin receptors have been identified in murine adipose tissue, the 3T3-L1 adipocyte cell line, and in human fat tissue. The...

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Publication status:
Published

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Authors


Isidori, AM More by this author
Frajese, V More by this author
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Journal:
Molecular and cellular endocrinology
Volume:
200
Issue:
1-2
Pages:
99-109
Publication date:
2003-02-05
DOI:
EISSN:
1872-8057
ISSN:
0303-7207
URN:
uuid:2f404f72-00c2-44df-9738-07ff09fe47ef
Source identifiers:
138328
Local pid:
pubs:138328

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