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Serum from postmenopausal women directs differentiation of human clonal osteoprogenitor cells from an osteoblastic toward an adipocytic phenotype.

Abstract:

A consistent observation in osteoporosis is bone volume reduction accompanied by increased marrow adipose tissue. No single cause linking the two phenomena has yet been identified. In a human progenitor cell clone (hOP 7) derived from bone marrow, however, we have demonstrated that rabbit serum can direct differentiation away from an osteoblast lineage to one of adipocytes. We now report on whether human serum has a similar effect. Serum was collected from 10 pre- and 10 postmenopausal women ...

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Publication status:
Published

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Publisher copy:
10.1007/s00223-007-9016-2

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Calcified tissue international
Volume:
80
Issue:
4
Pages:
233-243
Publication date:
2007-04-05
DOI:
EISSN:
1432-0827
ISSN:
0171-967X
URN:
uuid:2f3c280a-1710-4e2b-b979-c1b18ea5ff42
Source identifiers:
109239
Local pid:
pubs:109239

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