Thesis icon

Thesis

Small molecule tools for structural and functional studies of 2OG oxygenases

Abstract:

The work described in this thesis focused on members of the Fe(II), 2-oxoglutarate dependent oxygenase family that are involved in the biosynthesis of L-carnitine in mammals and in hypoxia sensing. Work on metallo β-lactamases was also carried out. Nϵ-Trimethyllysine hydroxylase (TMLH) and γ-butyrobetaine hydroxylase (BBOX) catalyse the first and final steps in carnitine biosynthesis, respectively. Chapter 1 provides an overview of the current l...

Expand abstract

Actions


Access Document


Files:

Authors


Robert Lesniak More by this author

Contributors

More from this funder
Grant:
106244/Z/14/Z
Funding agency for:
Project
More from this funder
Grant:
BB/L000121/1
Funding agency for:
Project
More from this funder
Grant:
RE/13/1/30181
Funding agency for:
Project
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP