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Genome-wide association study to identify genetic determinants of severe asthma

Abstract:

Background: The genetic basis for developing asthma has been extensively studied. However, association studies to date have mostly focused on mild to moderate disease and genetic risk factors for severe asthma remain unclear. Objective: To identify common genetic variants affecting susceptibility to severe asthma. Methods: A genome-wide association study was undertaken in 933 European ancestry individuals with severe asthma based on Global Initiative for Asthma (GINA) criteria 3 or above and ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


Shrine, NRG More by this author
Artigas, MS More by this author
Blakey, JD More by this author
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Publisher:
BMJ Publishing Group Publisher's website
Journal:
Thorax Journal website
Volume:
67
Issue:
9
Pages:
762-768
Publication date:
2012
DOI:
EISSN:
1468-3296
ISSN:
0040-6376
URN:
uuid:2f15ed4e-e94b-4680-9d88-665a1a2e2469
Source identifiers:
446299
Local pid:
pubs:446299
Language:
English

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