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Journal article

Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase.

Abstract:

The c-KIT receptor tyrosine kinase mediates the cellular response to stem cell factor (SCF). Whereas c-KIT activity is important for the proliferation of hematopoietic cells, melanocytes and germ cells, uncontrolled c-KIT activity contributes to the growth of diverse human tumors. Suppressor of cytokine signaling 6 (SOCS6) is a member of the SOCS family of E3 ubiquitin ligases that can interact with c-KIT and suppress c-KIT-dependent pathways. Here, we analyzed the molecular mechanisms that d...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m110.173526

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Journal:
The Journal of biological chemistry
Volume:
286
Issue:
1
Pages:
480-490
Publication date:
2011-01-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:2f15a373-9e02-4ccf-82b7-259cdb76d666
Source identifiers:
93032
Local pid:
pubs:93032

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