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Modes of interaction of pleckstrin homology domains with membranes: towards a computational biochemistry of membrane recognition

Abstract:

Pleckstrin homology (PH) domains mediate protein-membrane interactions by binding to phosphatidylinositol phosphate (PIP) molecules. The structural and energetic basis of selective PHPIP interactions is central to understanding many cellular processes, yet the molecular complexities of the PH-PIP interactions are largely unknown. Molecular dynamics (MD) simulations using a coarse-grained model enables estimation of free energy landscapes for the interactions of 12 different PH domains with me...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/j.jmb.2017.12.011

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Oxford college:
Christ Church
Leverhulme Trust More from this funder
University of Oxford More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Journal of Molecular Biology Journal website
Volume:
430
Issue:
3
Pages:
372-388
Publication date:
2017-12-20
Acceptance date:
2017-12-13
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
Pubs id:
pubs:811273
URN:
uri:2f0a7ac3-1513-4927-bf91-920106ea0584
UUID:
uuid:2f0a7ac3-1513-4927-bf91-920106ea0584
Local pid:
pubs:811273

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