Journal article
Synovial single-cell heterogeneity, zonation and interactions: a patchwork of effectors in arthritis
- Abstract:
- Despite extensive research, there is still no treatment that would lead to remission in all patients with rheumatoid arthritis as our understanding of the affected site, the synovium, is still incomplete. Recently, single-cell technologies helped to decipher the cellular heterogeneity of the synovium; however, certain synovial cell populations, such as endothelial cells or peripheral neurons, remain to be profiled on a single-cell level. Furthermore, associations between certain cellular states and inflammation were found; whether these cells cause the inflammation remains to be answered. Similarly, cellular zonation and interactions between individual effectors in the synovium are yet to be fully determined. A deeper understanding of cell signalling and interactions in the synovium is crucial for a better design of therapeutics with the goal of complete remission in all patients.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 560.8KB, Terms of use)
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- Publisher copy:
- 10.1093/rheumatology/keab721
Authors
- Publisher:
- British Society for Rheumatology
- Journal:
- Rheumatology More from this journal
- Volume:
- 61
- Issue:
- 3
- Pages:
- 913-925
- Publication date:
- 2021-09-24
- Acceptance date:
- 2021-09-13
- DOI:
- EISSN:
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1462-0332
- ISSN:
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1462-0324
- Pmid:
-
34559213
- Language:
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English
- Keywords:
- Pubs id:
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1198006
- Local pid:
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pubs:1198006
- Deposit date:
-
2022-01-17
Terms of use
- Copyright holder:
- Schonfeldova et al
- Copyright date:
- 2021
- Rights statement:
- © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact [email protected]
- Licence:
- CC Attribution (CC BY)
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