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In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate

Abstract:

Technical limitations for culturing the human malaria parasite Plasmodium vivax have impaired the discovery of vaccine candidates, challenging the malaria eradication agenda. The immunogenicity of the M2 domain of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) antigen cloned from the Plasmodium yoelii murine parasite, has been previously demonstrated.Detailed epitope mapping of MAEBL through immunoinformatics identified several MHCI, MHCII and B cell epitopes throughout the pepti...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Files:
Publisher copy:
10.1186/s12936-017-2144-x

Authors


Machado, RB More by this author
Suwanarusk, R More by this author
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Instituto Nacional de Ciência e Tecnologia de Vacinas More from this funder
Conselho Nacional de Desenvolvimento Científico e Tecnológico More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Malaria Journal Journal website
Volume:
17
Issue:
1
Pages:
Article: 20
Publication date:
2018-01-10
Acceptance date:
2017-12-18
DOI:
ISSN:
1475-2875
Pubs id:
pubs:817783
URN:
uri:2ee6263f-d353-4eb8-baf8-d64189646132
UUID:
uuid:2ee6263f-d353-4eb8-baf8-d64189646132
Local pid:
pubs:817783
Language:
English

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