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A comparison of clofarabine with ara-C, each in combination with daunorubicin as induction treatment in older patients with acute myeloid leukaemia

Abstract:

The study was designed to compare clofarabine plus daunorubicin vs daunorubicin/ara-C in older patients with acute myeloid leukaemia (AML) or high-risk myelodysplastic syndrome (MDS). Eight hundred and six untreated patients in the UK NCRI AML16 trial with AML/high-risk MDS (median age, 67 years; range 56–84) and normal serum creatinine were randomised to two courses of induction chemotherapy with either daunorubicin/ara-C (DA) or daunorubicin/clofarabine (DClo). Patients were also included i...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/leu.2016.225

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Subgroup:
Clinical Trial Service Unit
Role:
Author
ORCID:
0000-0003-0166-0062
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Cancer Research UK More from this funder
Publisher:
Springer Nature Publishing Group Publisher's website
Journal:
Leukemia Journal website
Volume:
31
Pages:
310-317
Publication date:
2016-09-02
Acceptance date:
2016-07-12
DOI:
EISSN:
1476-5551
ISSN:
0887-6924
Pubs id:
pubs:930220
URN:
uri:2ed6a2bb-b6fb-42bd-917d-5fdce7327164
UUID:
uuid:2ed6a2bb-b6fb-42bd-917d-5fdce7327164
Local pid:
pubs:930220

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